A new liquid biopsy approach developed by聽Johns Hopkins Kimmel Cancer Center investigators could revolutionize brain cancer detection by identifying circulating DNA fragments from tumors and immune cells in blood samples, potentially enabling earlier diagnosis.
Scientists have identified a key gene that regulates sugar metabolism and dramatically improves tomato fruit quality and resilience after harvest. The gene, known as SlVI, encodes a vacuolar invertase that plays a critical role in converting sucrose into glucose and fructose during fruit ripening. By knocking out SlVI, researchers achieved higher fruit sucrose levels, enhanced firmness, increased resistance to fungal infections, and an extended shelf life. These findings not only reveal new insights into sugar's dual role as both an energy source and signaling molecule but also open avenues for developing tastier and more durable fruits, addressing critical challenges in agriculture and food storage.
Metabolon Launches Microbiome Research Solution Combining New Microbiome Panel, Metagenomics Sequencing, and Multiomics Bioinformatics Tools
---- Lukas Scheibler, Ph.D. to become Chief Research and Development Officer and Graham Cooper to become Chief Financial Officer ---- Additions to senior team will drive Tavo's strategy to develop new innovative therapeutics addressing critical unmet needs in glaucoma and retinal disease
Some plants produce oils with properties that are particularly good for biofuels, but not all of these plants are suitable for being grown on a large scale. To solve this dilemma, scientists modified the seeds of camelina and pennycress to produce the same type of oil made by the burning bush plant. The result is plants that produce nearly pure, high-quality oil with improved biofuel properties.
A Ludwig Cancer Research study has identified a specific mode of fat uptake by immune cells within tumors that serves as a metabolic checkpoint against anti-cancer immune responses.
New UF blackberry varieties could provide a boon for farmers looking to rebound after the decline of Florida citrus and who see an opportunity to meet the growing demand for blackberries, which have soared in popularity in recent years.
Researchers have uncovered multiple new genes and genetic pathways that could lead to repurposing hundreds of existing drugs for osteoarthritis, the most common form of arthritis.
How did horses become some of the greatest athletes in the animal kingdom? Researchers at Johns Hopkins Medicine may have found the answer, pinpointing a genetic mutation and evolutionary process that occurred millions of years ago, which appears to have optimized horses鈥� speeds and stamina.
A recent study reveals that dimethyl fumarate (DMF), a compound already approved for other inflammatory diseases, can prevent and alleviate periodontal tissue damage. The research demonstrates that DMF significantly shifts immune cell behavior, promoting anti-inflammatory macrophages and restoring mitochondrial health by enhancing mitophagy鈥攁 cellular process that removes damaged mitochondria. The drug achieves this through regulation of Tu translation elongation factor (TUFM), a protein critical to mitochondrial function. This breakthrough suggests a new therapeutic approach for periodontitis by targeting mitochondrial quality control and immune modulation rather than relying solely on traditional plaque-removal strategies.
A recent study led by Prof. Haim Cohen at Bar-Ilan University, in collaboration with Dr. Sagi Snir and PhD student Sarit Feldman-Trabelsi, explores why some mammals live much longer and healthier lives than others.
Oral submucous fibrosis (OSF) is a serious disease that impairs mouth functionality, often leading to restricted opening and a high risk of malignant transformation. New research has uncovered a crucial player in this disease: cartilage oligomeric matrix protein (COMP).
Patients with locally advanced head and neck cancer who received the immune checkpoint inhibitor pembrolizumab before, during and after standard-of-care surgery had longer event-free survival without the cancer coming back and higher rates of substantial tumor shrinkage prior to surgery, according to the first interim analysis of a randomized, open-label phase 3 clinical trial led by investigators from Dana-Farber Brigham Cancer Center and Washington University School of Medicine in St. Louis.
BACKGROUNDStem cells from apical papilla (SCAPs) represent promising candidates for bone regenerative therapies due to their osteogenic potential. However, enhancing their differentiation capacity remains a critical challenge. Enhancer of z
BACKGROUNDMesenchymal stem cell (MSC)-based therapy may be a future treatment for myocardial infarction (MI). However, few studies have assessed the therapeutic efficacy of adipose tissue-derived MSCs (ADSCs) obtained from elderly patients
BACKGROUNDIn vivo degradation of bone scaffolds is significantly influenced by osteoclast (OC) activity, which is orchestrated by the interplay between receptor activator of nuclear factor-kappa B ligand (RANKL) and osteoprotegerin (OPG). T
Endometrial thickness plays an important role in successful embryo implantation and normal pregnancy achievement. However, a thin endometrial layer (鈮� 7 mm) may have a significant effect on microenvironment tolerance, which is further rel
Intervertebral disc degeneration is a leading cause of lower back pain and is characterized by pathological processes such as nucleus pulposus cell apoptosis, extracellular matrix imbalance, and annulus fibrosus rupture. These pathological
BACKGROUNDThere is currently no effective treatment for osteoarthritis (OA), which is the most common joint disorder leading to disability. Although human umbilical cord mesenchymal stem cells (hUC-MSCs) are promising OA treatments, their u
BACKGROUNDThin endometrium, leading cause of recurrent implantation failure and infertility, has been found to respond to exosomes. AIMTo investigate the efficacy of exosomes in addressing the issue of thin endometrium. METHODSRNA sequenc
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