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鈥� Phase I trial demonstrates lasting responses and encouraging safety profile in two aggressive thyroid cancer subtypes, suggesting further progress for CAR T cell therapy in solid tumors 鈥� One patient experienced a complete response, and one patient had a partial response 鈥� This type of cancer has limited treatment options, and most patients have a poor prognosis of six months or less 鈥� AIC100 is a CAR T cell therapy that targets the ICAM-1 protein on tumor cells

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鈥� Zongertinib, a HER2-targeted therapy made by Boehringer Ingelheim, demonstrated promising results in HER2-mutant lung cancer

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Artificial intelligence models, pretrained on vast datasets, significantly outperformed a standard baseline model in identifying nonmelanoma skin cancers (NMSC) from digital images of tissue samples, according to research presented at the American Association for Cancer Research (AACR) Annual Meeting, held April 25-30.

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UCLA researchers demonstrated that a novel topical BRAF inhibitor gel called LUT014 significantly reduces the severity of an acne-like rash, a common and painful side effect experienced by patients undergoing anti-EGFR therapies for colorectal cancer.

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鈥� RO7589831, a new drug from Roche, is first in a new class of drugs called Werner helicase inhibitors 鈥� Drug works similarly to other DNA damage repair inhibitors, such as PARP inhibitors 鈥� This class of drugs is important because many solid tumor patients with microsatellite instability (MSI) do not benefit from currently approved immunotherapies 鈥� Encouraging early results in this first-in-human trial prompted additional trial cohorts to optimize recommended dose for future clinical development

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New results from a clinical trial led by Memorial Sloan Kettering Cancer Center (MSK), demonstrate how immunotherapy alone can allow people with MMRd cancers to avoid surgery and preserve their quality of life. The results, presented at the 2025 American Association of Cancer Research (AACR) Annual Meeting and published simultaneously in The New England Journal of Medicine (NEJM), found that 80 percent of patients did not require surgery, radiation, or chemotherapy after six months of treatment with immunotherapy alone.

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An international phase 3 clinical trial led by Washington University School of Medicine in St. Louis and Dana-Farber Brigham Cancer Center shows that patients with certain locally advanced head and neck cancers benefited from the addition of the immunotherapy drug pembrolizumab (brand name Keytruda) to standard-of-care therapy. Patients who received pembrolizumab saw greater tumor shrinkage prior to surgery and, on average, survived cancer-free almost two years longer than did patients who only received standard-of-care therapy.

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Patients with locally advanced head and neck cancer who received the immune checkpoint inhibitor pembrolizumab before, during and after standard-of-care surgery had longer event-free survival without the cancer coming back and higher rates of substantial tumor shrinkage prior to surgery, according to the first interim analysis of a randomized, open-label phase 3 clinical trial led by investigators from Dana-Farber Brigham Cancer Center and Washington University School of Medicine in St. Louis.

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Ludwig Cancer Research is proud to support eight early-career scientists presenting their research at the conference this year through the AACR Scholar-in-Training Awards (SITA) program, contributing to the cost of their travel and attendance at the conference.

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Ludwig Cancer Research released today the full scope of research to be presented by Ludwig-affiliated scientists at the American Association for Cancer Research (AACR) Annual Meeting 2025, which will be held online and in person in Chicago, from April 25 to April 30.

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A new targeted drug treatment for small cell lung cancer, understanding how obesity drives endometrial cancer, and predicting early-stage melanoma spread are among the research topics being presented by scientists with The Ohio State University Comprehensive Cancer Center 鈥� Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at the American Association for Cancer Research Annual Meeting April 25-30 in Chicago.

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A woman smashed a longstanding world record in the 200-meter sprint at the age of 91, prompting scientists to delve into her physiology to learn how she can run so fast. Researchers will present their findings at the 2025 American Physiology Summit in Baltimore. The Summit is the flagship annual meeting of the American Physiological Society (APS).

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A study conducted in mice suggests that daily exercise could help to counteract some of the negative impacts of college-age drinking later in life.

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Erythritol, a commonly used sugar substitute often marketed as 鈥渉ealthy,鈥� may impair blood vessel health by disrupting the brain鈥檚 ability to produce a critical compound, according to new research. Scientists will present their findings at the 2025 American Physiology Summit in Baltimore. The Summit is the flagship annual meeting of the American Physiological Society (APS).

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Despite clear health warnings, many Americans have a hard time shaking the salt habit. New research suggests that consuming more potassium could help salt-lovers dodge some of the dangers.

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Ever notice how going for a run on an 80-degree day feels scorching in the spring but comfortable at the end of August? New research shows that the reason for this is that we gradually lose our tolerance for heat during cold seasons, but it鈥檚 possible to regain it with a brief regimen of hot and humid workouts.

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Simply watching virtual reality (VR) scenes of a warm environment during exercise may influence physiologic processes that control body temperature. Early findings suggest that viewing hot scenes increases sweating, helping the body cool down more efficiently during exercise. Researchers will present their findings at the 2025 American Physiology Summit in Baltimore. The Summit is the flagship annual meeting of the American Physiological Society (APS).

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New research suggests that lycopene, which gives fruits like tomatoes and watermelons their bright red color, supports healthy liver functioning and may help prevent weight gain.

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Getting enough exercise can be especially helpful鈥攁nd especially challenging鈥攆or people with Parkinson鈥檚 disease. In a new study, patients who received a weekly email newsletter with Parkinson鈥檚-specific exercise tips saw a significant improvement in exercise capacity after 12 weeks.

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The American Physiological Society (APS) is pleased to announce Wolfgang M. Kuebler, PhD, MD, FAPS, as the recipient of the 2025 Presidential Service Award.