News Curated �鶹��ý Channel: Cell (journal)

How A Small Number of Mutations Can Fuel Outbreaks of Western Equine Encephalitis Virus

Harvard Medical School — Fri, 04 Apr 2025 11:00:00 EST

New research shows how small shifts in the molecular makeup of a virus can profoundly alter its fate. These shifts could turn a deadly pathogen into a harmless bug or supercharge a relatively benign virus, influencing its ability to infect humans and cause dangerous outbreaks.

Virus Infects Cells with a Protective Cloaking Mechanism

University of California San Diego — Thu, 03 Apr 2025 20:40:06 EST

Viruses known as "jumbo phage" are a new hope against the rising antibacterial infection crisis. Researchers have discovered how jumbo phage are able to infect bacteria so efficiently. They found a compartment that protects and hides valuable DNA material from the bacteria's immune defense system.

Researchers Find Intestinal Immune Cell Prevents Food Allergies

Washington University in St. Louis — Thu, 03 Apr 2025 20:10:42 EST

Researchers at WashU Medicine found that a small population of immune cells in the mouse intestine prevents allergic responses to food, suggesting that targeting such cells therapeutically could potentially lead to a new treatment for allergies.

Delicate Balancing Act Determines How Many Genome Gateways Form in Cells

Sanford Burnham Prebys — Mon, 31 Mar 2025 11:00:00 EST

As warehouses go, nuclei are more like libraries than bank vaults. Too many cellular components need access to the genome to lock it down like Fort Knox. Instead, large groupings of more than 1,000 individual protein molecules called nuclear pore complexes (NPCs) pepper the dividing membrane, serving as gateways for materials and messages entering and exiting the nucleus.

Personalized App Reduces Cancer-Related Fatigue

Michigan Medicine - University of Michigan — Thu, 27 Mar 2025 09:10:00 EST

U-M researchers, in collaboration with Arcascope, have developed and tested a personalized app that tracks a user's circadian rhythm and makes behavioral recommendations to reduce daily fatigue.

Why Brain Metastases of Breast Cancer Resist a Promising Candidate Therapy

Ludwig Cancer Research — Mon, 24 Mar 2025 18:10:15 EST

A Ludwig Cancer Research study has identified a key barrier to the efficacy of a promising combination of radiotherapy and immunotherapy for the treatment of brain metastases arising from breast cancer--and in doing so uncovered approaches to overcoming that resistance.

Study Identifies Gut Sensor That Propels Intestines To Move

Harvard Medical School — Mon, 24 Mar 2025 11:00:00 EST

Research in mice identifies protein responsible for regulating gut movement in response to pressure, exercise, and inflammation. The findings can inform precision-targeted treatments for intestinal inflammation and disorders of gut motility. The results add to a growing body of research showing the nervous and immune systems interact in various organs, including the brain, lungs, and skin.

New Study Sheds Light on How Bacteria 'Vaccinate' Themselves with Genetic Material from Dormant Viruses

Johns Hopkins Medicine — Fri, 21 Mar 2025 17:45:44 EST

Johns Hopkins Medicine scientists say they have shed new light on how bacteria protect themselves from certain phage invaders -- by seizing genetic material from weakened, dormant phages and using it to "vaccinate" themselves to elicit an immune response.

Scientists Demonstrate Pre-clinical Proof of Concept for Next-Gen DNA Delivery Technology

Wistar Institute — Fri, 21 Mar 2025 11:05:00 EST

Wistar Institute scientists and collaborators describe a next-generation vaccination technology that combines plasmid DNA with a lipid nanoparticle delivery system.

Boosting Brain's Waste Removal System Improves Memory in Old Mice

Washington University in St. Louis — Fri, 21 Mar 2025 11:00:00 EST

Aging compromises the lymphatic vessels surrounding the brain, disabling waste drainage from the brain and impacting cognitive function. Researchers at WashU Medicine boosted lymphatic vessel integrity in old mice and found improvements in their memory compared with old mice without rejuvenated lymphatic vessels.

New Drug Therapy Combination Shows Promise for Advanced Melanoma Patients

Huntsman Cancer Institute at the University of Utah — Fri, 21 Mar 2025 10:25:45 EST

A novel oral combination drug therapy evaluated at Huntsman Cancer Institute could treat and prevent melanoma spreading to the brain. Brain metastasis is the main cause of death from melanoma.

Researchers Find Missing Link in Autoimmune Disorder

Washington University in St. Louis — Tue, 18 Mar 2025 20:55:25 EST

Scientists at Washington University School of Medicine in St. Louis and the Perelman School of Medicine at the University of Pennsylvania have identified a key component to launching immune activity - and overactivity. The researchers identified a protein in cells that spurs the release of infection-fighting molecules. The protein, whose role in the immune system had not previously been suspected, provides a potential target for therapies that could prevent overreactive immune responses that are at the root of several debilitating illnesses.

A New Way to Predict Cancer's Spread? Scientists Look at 'Stickiness' of Tumor Cells

University of California San Diego — Wed, 05 Mar 2025 11:00:00 EST

By assessing how "sticky" tumor cells are, UC San Diego researchers have found a potential way to predict whether a patient's early-stage breast cancer is likely to spread. The discovery could help doctors identify high-risk patients and tailor their treatments accordingly.

New HIV Vaccine Candidate Discovered with Help From Argonne's Advanced Photon Source

Argonne National Laboratory — Tue, 04 Mar 2025 16:40:07 EST

Protein crystallization at the SER-CAT beamline at Argonne's Advanced Photon Source proved key to the discovery of a new HIV vaccine candidate.

New X-Ray Technology Captures Proteins in Motion

University of Chicago Medical Center — Thu, 27 Feb 2025 19:10:49 EST

Researchers at UChicago, Argonne, and Harvard perfected a new technique for creating experimental movies of proteins in action.

How Solving a Hepatitis B Paradox Opened the Door to New Therapies

Rockefeller University — Thu, 27 Feb 2025 16:50:21 EST

New Technique Reveals How the Same Mutations Give Rise to Very Different Types of Leukaemia

Fundacio Institut de Recerca Biomedica (IRB BARCELONA) — Tue, 25 Feb 2025 18:20:00 EST

* A study from IRB Barcelona, funded by Fundacion CRIS contra el cancer demonstrates that the "previous state" of blood stem cells plays a decisive role in the subtype of leukaemia that develops. * The new technique, called STRACK, allows monitoring of the evolution of each cell before and after acquiring oncogenic mutations.

Research Suggests Common Viral Infection Worsens Deadly Condition Among Premature Babies

Johns Hopkins Medicine — Mon, 24 Feb 2025 19:00:16 EST

Johns Hopkins researchers say they found that infection with a common virus that can be transmitted from mother to fetus before birth significantly worsens an often-fatal complication of premature birth called necrotizing enterocolitis (NEC) in experiments with mice.

Mystery Solved: New Study Reveals How DNA Repair Genes Play a Major Role in Huntington's Disease

University of California, Los Angeles (UCLA), Health Sciences — Tue, 11 Feb 2025 11:00:00 EST

A new UCLA Health study has discovered in mouse models that genes associated with repairing mismatched DNA are critical in eliciting damages to neurons that are most vulnerable in Huntington's disease and triggering downstream pathologies and motor impairment, shedding light on disease mechanisms and potential new ways to develop therapies.

Research Pinpoints Weakness in Lung Cancer's Defenses

Harvard Medical School — Mon, 10 Feb 2025 22:00:00 EST

Scientists uncover an enzyme that boosts cancer cell metabolism to fuel growth