News Feature Channel: Drug Resistance

A light-activated probe reveals TB immune system evasion mechanisms

American Chemical Society (ACS) — Mon, 21 Apr 2025 10:55:05 EST

The pathogen that causes tuberculosis is deadly in part because of its complex outer envelope, which helps it evade immune responses of infected hosts. In an ACS Infectious Diseases paper, researchers developed a chemical probe to study a key component of this envelope. Their results provide a step toward finding new ways of inactivating the bacterium.

Study Suggests Experimental Cancer Drug Could Streamline Standard Tuberculosis Treatment and Prevent Post-TB Lung Disease

Johns Hopkins Medicine — Mon, 21 Apr 2025 08:00:56 EST

An experimental drug now in clinical trials as a cancer treatment could help boost the power of first-line tuberculosis (TB) treatments by helping infected cells die a gentler death, Johns Hopkins Medicine investigators report.

You Can Heal More Wounds with Honey

Universite de Montreal — Tue, 15 Apr 2025 17:20:58 EST

UdeM pharmacy professor Simon Matoori has reviewed studies on the therapeutic properties of honey in the treatment of both acute and chronic wounds.

Estudio: La estimulacion cerebral profunda personalizada podria tratar la epilepsia resistente a los farmacos

Mayo Clinic — Thu, 10 Apr 2025 09:25:23 EST

Un estudio publicado en Brain Communications destaca un nuevo enfoque para el tratamiento de la epilepsia resistente a los medicamentos. Los investigadores de Mayo Clinic han desarrollado una plataforma innovadora de estimulacion cerebral profunda (DBS, del ingles Deep Brain Stimulation) que se ha utilizado no solo para reducir las convulsiones, sino tambien para mejorar la memoria y el sueno, dos desafios comunes para los pacientes con epilepsia.

Estudo: Estimulacao cerebral profunda personalizada pode tratar epilepsia resistente a medicamentos

Mayo Clinic — Thu, 10 Apr 2025 09:15:15 EST

Um estudo publicado na Brain Communications destaca uma nova abordagem para o tratamento da epilepsia resistente a medicamentos. Pesquisadores da Mayo Clinic desenvolveram uma plataforma inovadora de estimulacao cerebral profunda ((DBS, do ingles Deep Brain Stimulation) que foi utilizada nao apenas para reduzir as crises, mas tambem para melhorar a memoria e o sono -- dois desafios comuns para pacientes com epilepsia.

دراسة جديدة في مجلة Brain Communications تتوصل إلى أن التحفيز العميق المخصَّص للدماغ يُظهر نتائج واعدة في علاج الصرع المقاوم للأدوية

Mayo Clinic — Thu, 10 Apr 2025 00:05:50 EST

روتشستر، ولاية مينيسوتا -- تسلِّط دراسة جديدة نُشرت في مجلة اتصالات الدماغ (Brain Communications) الضوء على طريقة جديدة لعلاج الصرع المقاوم للأدوية. طوّر الباحثون في مايو كلينك منصة مبتكرة للتحفيز العميق للدماغ والتي استُخدمت ليس فقط لتقليل النوبات، ولكن أيضًا لتحسين الذاكرة والنوم -- وهما تحديان شائعان لمرضى الصرع.

New Breakthrough Combats Lenalidomide Resistance in Multiple Myeloma

National University of Singapore (NUS) — Wed, 09 Apr 2025 21:40:49 EST

A new study conducted by researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore has uncovered a key mechanism behind lenalidomide resistance in multiple myeloma (MM), offering new insights into potential strategies for improving treatment outcomes and overcoming drug resistance.

UC San Diego Health Named Region's Only Level 4 Adult Epilepsy Center

UC San Diego Health — Tue, 08 Apr 2025 20:25:23 EST

New Study in Brain Communications Finds Personalized Deep Brain Stimulation Shows Promise for Drug-Resistant Epilepsy

Mayo Clinic — Mon, 07 Apr 2025 14:50:48 EST

A study published in Brain Communications highlights a new approach to treating drug-resistant epilepsy. Researchers at Mayo Clinic have developed an innovative deep brain stimulation (DBS) platform that was used to not only reduce seizures, but also improve memory and sleep -- two common challenges for patients with epilepsy.

Virus Infects Cells with a Protective Cloaking Mechanism

University of California San Diego — Thu, 03 Apr 2025 20:40:06 EST

Viruses known as "jumbo phage" are a new hope against the rising antibacterial infection crisis. Researchers have discovered how jumbo phage are able to infect bacteria so efficiently. They found a compartment that protects and hides valuable DNA material from the bacteria's immune defense system.

Study Reveals New Details on How Virus Builds Protective Shell

Indiana University — Wed, 02 Apr 2025 10:50:22 EST

A research team at Indiana University Bloomington has uncovered new details about how a tiny virus builds its protective outer shell --a crucial part of its ability to infect cells.

Sensors Against Superbugs

Empa, Swiss Federal Laboratories for Materials Science and Technology — Tue, 01 Apr 2025 05:00:32 EST

Antibiotic-resistant bacteria can cause life-threatening infections that are almost impossible to treat with existing medication. As a result, common illnesses such as urinary tract infections or skin wounds are becoming a health risk. Empa researchers are therefore working on sensors that quickly identify resistant germs and recommend efficient treatment.

Lasso-Shaped Antibiotic Co-Developed by UIC Evades Standard Drug Resistance

University of Illinois Chicago — Wed, 26 Mar 2025 12:00:15 EST

A small molecule shaped like a lasso may be a powerful tool in the fight against infectious diseases, according to a new study in Nature co-authored by University of Illinois Chicago researchers.

A Breakthrough Moment: McMaster Researchers Discover New Class of Antibiotics

McMaster University — Wed, 26 Mar 2025 12:00:00 EST

A McMaster University team led by renowned researcher Gerry Wright has identified a strong candidate to challenge even some of the most drug-resistant bacteria on the planet: a new molecule called lariocidin.

To Overcome Antibiotic Resistance, New Research Says to Let It Flow

College of Liberal Arts and Sciences, University of Illinois Urbana-Champaign — Thu, 20 Mar 2025 18:15:36 EST

Some notoriously difficult to treat infections may not be as resistant to antibiotics as has been thought, according to University of Illinois research using a microfluidic device that more closely duplicates the fluid flow found in the body.

Improving Epilepsy Surgery by Pinpointing Where Seizures Begin

University of California, San Francisco (UCSF) — Tue, 18 Mar 2025 08:00:00 EST

The study, appearing in the March 25 edition of eBioMedicine (open-access journal from The Lancet), found that using intracranial EEG recordings with high-density arrays resulted in better appraisals and better agreement about the location of SOZ among the epileptologists, compared to lower-density recordings.

New CRISPR-Based Diagnostic Test Detects Pathogens in Blood Without Amplification

University Of Illinois Grainger College Of Engineering — Fri, 14 Mar 2025 20:50:49 EST

UC Irvine Scientists Invent New Drug Candidates to Treat Antibiotic-Resistant Bacteria

University of California, Irvine — Mon, 24 Feb 2025 19:05:39 EST

Irvine, Calif., Feb. 24, 2025 -- There's an arms race in medicine - scientists design drugs to treat lethal bacterial infections, but bacteria can evolve defenses to those drugs, sending the researchers back to square one. In the Journal of the American Chemical Society, a University of California, Irvine-led team describes the development of a drug candidate that can stop bacteria before they have a chance to cause harm.

Why Anti-TNF Drugs Don't Work for Some Kids with Crohn's Disease

Michigan Medicine - University of Michigan — Wed, 12 Feb 2025 21:55:58 EST

Research from Michigan Medicine has investigated possible genetic factors for drug efficacy for children with Crohn's disease. In this latest study, HLA DQA1*05 positive children just taking anti-TNF mediation had the highest rate of drug failure.

Diabetes Can Drive the Evolution of Antibiotic Resistance

University of North Carolina School of Medicine — Wed, 12 Feb 2025 14:00:00 EST

Researchers at the UNC School of Medicine have proven that antibiotic-resistant strains of a harmful bacteria thrive in a diabetic infection environment.