A pioneering study has unveiled a revolutionary technique that enhances stem cell therapy for neurodegenerative diseases by combining magnetic guidance with localized ultrasound stimulation. This innovative approach successfully navigates magnetically loaded stem cells to specific brain regions and promotes their differentiation into neurons using a miniaturized ultrasound device.
BACKGROUNDMesenchymal stem cell-derived extracellular vesicles (MSC-EVs) can traverse the blood-brain barrier due to their small size. This characteristic makes them a research hotspot for the treatment of Parkinson鈥檚 disease (PD) and is
Getting enough exercise can be especially helpful鈥攁nd especially challenging鈥攆or people with Parkinson鈥檚 disease. In a new study, patients who received a weekly email newsletter with Parkinson鈥檚-specific exercise tips saw a significant improvement in exercise capacity after 12 weeks.
An international research collaboration led by Rutgers University-New Brunswick scientists that examined microscopic blobs of protein found in human cells has discovered that some morph from an almost honey-like substance to a hard candy-like solid. These mysterious droplets, known as biomolecular condensates, solidify when they carry a high proportion of the protein alpha-synuclein, the scientists reported in Science Advances. Clumps of alpha-synuclein are commonly found in the brain cells of people with Parkinson鈥檚 disease, a neurodegenerative brain disorder.
A groundbreaking open-source computer program uses artificial intelligence to analyze videos of patients with Parkinson's disease and other movement disorders. The tool, called VisionMD, helps doctors more accurately monitor subtle motor changes, improving patient care and advancing clinical research.
The latest research advances from Cedars-Sinai investigators.
The Focused Ultrasound Foundation today announced a historic achievement for the field of noninvasive medicine: more than one million patients worldwide have now been treated with focused ultrasound.
Scientists at Johns Hopkins Medicine say they have discovered how a group of proteins linked to Parkinson鈥檚 disease and amyotrophic lateral sclerosis act as 鈥済uardians鈥� of mitochondria, small organelles, or subunits, within a cell that make and store energy and are found in almost all plants and animals.
NASA Awards NSCF $3.1M to Continue Studying Effects of Microgravity on Brain Cells
As March Madness sweeps the nation and college basketball takes center stage, a former coach鈥檚 journey off the court is proving just as inspiring as any Cinderella story on the hardwood.聽Billy Kennedy, former head coach of Texas A&M, has spent his career developing game plans, mentoring players, and leading teams through the highs and lows of competition.
The brains of babies delivered before 37 weeks鈥� gestation show weaker neural connections between key brain regions compared with those of full-term infants, a recent Cedars-Sinai study shows.
A stem cell therapy trial aimed at reducing neuroinflammation in patients with presymptomatic Alzheimer鈥檚 disease is underway at UTHealth Houston.
Pesquisadores da Mayo Clinic descobriram uma nova maneira de detectar e monitorar com mais precis茫o a atividade das c茅lulas cerebrais durante a estimula莽茫o cerebral profunda, um tratamento comum para dist煤rbios do movimento, como鈥痑 doen莽a de Parkinson鈥痚 tremor. Essa precis茫o pode ajudar os m茅dicos a ajustar a coloca莽茫o e a estimula莽茫o dos eletrodos em tempo real, proporcionando um atendimento melhor e mais personalizado aos pacientes que recebem o procedimento cir煤rgico. O鈥痚studo鈥痚st谩 publicado no Journal of Neurophysiology.
Investigadores de Mayo Clinic han descubierto una nueva manera de detectar y monitorear con mayor precisi贸n la actividad de las c茅lulas cerebrales durante la estimulaci贸n cerebral profunda, un tratamiento com煤n para los trastornos del movimiento como la enfermedad de Parkinson鈥痽 temblor. Esta precisi贸n puede ayudar a los m茅dicos a ajustar la colocaci贸n y la estimulaci贸n de los electrodos en tiempo real, brindando una atenci贸n mejor y m谩s personalizada a los pacientes que reciben el procedimiento quir煤rgico. El鈥痚studio鈥痵e publica en Journal of Neurophysiology.
Mayo Clinic researchers have found a new way to more precisely detect and monitor brain cell activity during deep brain stimulation, a common treatment for movement disorders such as鈥疨arkinson's disease鈥痑nd tremor.
乇賵鬲卮爻鬲乇貙 賵賱丕賷丞 賲賷賳賷爻賵鬲丕鈥� 丕賰鬲卮賮 亘丕丨孬賵賳 賲丕賷賵 賰賱賷賳賰 胤乇賷賯丞 噩丿賷丿丞 賱乇氐丿 賳卮丕胤 丕賱禺賱丕賷丕 丕賱丿賲丕睾賷丞 賵賲乇丕賯亘鬲賴丕 亘氐賵乇丞 兀丿賯 禺賱丕賱 丕賱鬲賳亘賷賴 丕賱毓賲賷賯 賱賱丿賲丕睾貙 賵賴賵 毓賱丕噩 卮丕卅毓 賱丕囟胤乇丕亘丕鬲 丕賱丨乇賰丞 賲孬賱 丿丕亍 亘丕乇賰賷賳爻賵賳 賵丕賱乇購毓丕卮. 賵賯丿 鬲爻丕毓丿 賴匕賴 丕賱丿賯丞 丕賱兀胤亘丕亍 毓賱賶 鬲毓丿賷賱 賵囟毓賷丞 丕賱兀賯胤丕亘 丕賱賰賴乇亘丕卅賷丞 賵丕賱鬲賳亘賷賴 賮賷 丕賱賵賯鬲 丕賱賮毓賱賷貙 賲賲丕 賷賵賮乇 乇毓丕賷丞 兀賮囟賱 賵兀賰孬乇 鬲禺氐賷氐賸丕 賱賱賲乇囟賶 丕賱賲鬲賱賯賷賳 賱賴匕丕 丕賱廿噩乇丕亍 丕賱噩乇丕丨賷. 賳購卮乇鬲 丕賱丿乇丕爻丞 賮賷 賲噩賱丞 丕賱賮賷夭賷賵賱賵噩賷丕 丕賱毓氐亘賷丞 (Journal of Neurophysiology).
Long-term and precise intracellular signal detection is critical for advancing our understanding of brain diseases and developing effective diagnostic tools. A breakthrough method has been introduced to enhance the stability and fidelity of recording signals at the single-cell level using ultrafine electrodes (UME). By controlling the tip exposure of UMEs, researchers have demonstrated a significant improvement in their ability to resist environmental interference, thus improving signal-to-noise ratio and sensitivity, and the collection area has been precisely controlled. This method promises to enhance the performance of implantable neural interfaces for real-time monitoring of intracellular signals.
UC Irvine School of Medicine podcast with Dr. Albert LaSpada on Ataxia
People with obstructive sleep apnea have an increased risk of Parkinson鈥檚 disease, but if started early enough, continuous positive airway pressure (CPAP) may reduce that risk, according to a preliminary study released today, March 2, 2025, that will be presented at the American Academy of Neurology鈥檚 77th Annual Meeting taking place April 5鈥�9, 2025, in San Diego and online. The study found using CPAP within two years of a sleep apnea diagnosis reduced the risk of Parkinson鈥檚.
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