Although rheumatoid arthritis is an autoimmune disease with no cure, a tailored, multidisciplinary treatment approach at Cedars-Sinai鈥檚 Inflammatory Arthritis Clinical Center helps patients get back to the activities they enjoy.
Indiana University School of Medicine scientists have developed a new imaging technique to study bone marrow in mouse models. This advancement could support future drug development and therapies for conditions involving bone marrow, including cancers, autoimmune diseases and musculoskeletal disorders.
Wistar and collaborators have discovered a type of 鈥渕olecular glue鈥� that can be used to inhibit certain pathological protein interactions.
Those who suffer myasthenia gravis experience muscle weakness that can affect the muscles we use to blink, smile and move our bodies. Researchers at UC San Diego鈥檚 School of Biological Sciences used a cutting-edge imaging technique to uncover new details about the mechanisms underlying the disease.
In a study of the immune systems of mice, scientists at Johns Hopkins Medicine say they have found a new role for a protein, QRICH1, which could become a target for drugs to dial up or down the activation of T cells to fight cancers and autoimmune diseases.
Research in mice shows that inflammatory molecules influence mood and behavior by acting on specific brain regions. The findings help explain why some people experience lasting mood changes after infections or autoimmune disease flare-ups. The research could lead to new therapies for anxiety disorders and autism spectrum disorders
A significant discovery has identified a missing "gatekeeper" protein as the root cause of dry mouth in Sj枚gren's syndrome 鈥� a finding that could change the way the disease is treated. Researchers pinpointed tricellulin, a protein that helps seal the junctions between saliva gland cells, as the key factor. When inflammation damages tricellulin, saliva production stops and harmful substances leak through.
Parents of children who have been diagnosed with multiple sclerosis likely have many questions about their child鈥檚 condition. Receiving a diagnosis can be overwhelming and searching for information online can turn up complicated explanations.Laura Saucier, MD, MSc, a neuroimmunologist in the Neurological Institute at Children鈥檚 Hospital Los Angeles, breaks down the key information that parents should know about multiple sclerosis (MS).
For years, an unnamed disease slowly stole one man's sight鈥攗ntil his son鈥檚 diagnosis finally provided the answer. Their journey highlights how rare disease research can unravel medicine's most elusive mysteries and, in doing so, can help reshape the future of medicine.
Researchers are studying messenger RNA鈥檚 potential to treat and prevent an array of serious conditions鈥攊ncluding cancer.
COVID infection has been linked to higher risk of autoimmune disorders, including rheumatoid arthritis and type 1 diabetes. Scientists used advanced data analysis and machine learning to identify viral proteins that are more likely to trigger autoimmunity.
Nebraska undergrads uncover ancient secrets of human immunity
New research from the University of Chicago shows how a specially trained population of immune cells keeps the peace by preventing other immune cells from attacking their own.
Scientists at Washington University School of Medicine in St. Louis and the Perelman School of Medicine at the University of Pennsylvania have identified a key component to launching immune activity 鈥� and overactivity. The researchers identified a protein in cells that spurs the release of infection-fighting molecules. The protein, whose role in the immune system had not previously been suspected, provides a potential target for therapies that could prevent overreactive immune responses that are at the root of several debilitating illnesses.
Protein kinase research presents an opportunity to explore molecular targets in the body to treat diseases like cancer and autoimmune disorders. These enzymes have the potential to bind to cellular sites and inhibit dysfunctional behavior, such as the overproduction of cancerous cells and tumor formation.
Two new studies led by researchers at Hospital for Special Surgery (HSS) have uncovered key biological mechanisms driving systemic sclerosis (SSc), or scleroderma 鈥� a rare and often devastating autoimmune disease that causes fibrosis (tissue hardening) and inflammation. The research, published in the March issue of the Journal of Experimental Medicine, helps explain why the disease disproportionately affects women and reveals potential treatment targets, some of which are already in development.
A new study of hundreds of patient records has added to evidence that it鈥檚 likely best to use as little corticosteroid medicine as possible when treating people who have lupus, a common heart complication of the autoimmune disorder.
"If we can target these molecules in human patients, they might be able to develop long-lasting tolerance to allergens."
A sponge-like implant in mice helped guide a treatment that slowed or stopped a degenerative condition similar to multiple sclerosis in humans. It also gave University of Michigan researchers a first look at how primary progressive multiple sclerosis, the fastest-progressing version of the disease, attacks the central nervous system early on.
Pesquisadores da Mayo Clinic identificaram uma terapia direcionada que pode trazer al铆vio para as pessoas que vivem com l铆quen plano, uma condi莽茫o inflamat贸ria cr么nica da pele, cabelo, unhas, boca e genitais. Eles descreveram suas descobertas em um estudo publicado no Journal of Clinical Investigation, relatando seu primeiro ensaio cl铆nico em humanos, fase 2.
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