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More than 100 experts in molecular simulation, coordinated by IRB Barcelona, have published an article in Nature Methods advocating for a paradigm shift in molecular dynamics data management. The article defends the implementation of the FAIR principles (Findable, Accessible, Interoperable, Reusable) to improve the reproducibility of calculations and facilitate their later use as a source of information on the flexibility of biomacromolecules. Led by Drs. Modesto Orozco and Adam Hospital, the article proposes the establishment of a shared infrastructure for storing and reusing data in the context of the AI revolution.

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How did horses become some of the greatest athletes in the animal kingdom? Researchers at Johns Hopkins Medicine may have found the answer, pinpointing a genetic mutation and evolutionary process that occurred millions of years ago, which appears to have optimized horses鈥� speeds and stamina.

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Ulrich Steidl, M.D., Ph.D., professor and chair of cell biology at Albert Einstein College of Medicine and deputy director at the National Cancer Institute-designated Montefiore Einstein Comprehensive Cancer Center, has been elected a member of the Association of American Physicians (AAP), a prestigious 140-year-old honorary society dedicated to advancing medical knowledge through basic and clinical science.

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A recent study has revealed that KIAA1199, a secreted protein produced by bone marrow cells, plays a crucial role in regulating both fat formation and overall energy metabolism. The protein's impact extends beyond bone remodeling, influencing glucose and lipid metabolism. Mice lacking KIAA1199 showed reduced fat mass, improved insulin sensitivity, and a decreased risk of obesity-related diseases. These findings suggest that targeting KIAA1199 could lead to new therapeutic strategies for combating metabolic disorders like obesity and type 2 diabetes.

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Scientists at St. Jude Children鈥檚 Research Hospital and the Medical College of Wisconsin have discovered how chemokines and G protein-coupled receptors selectively bind each other to control how cells move.

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Un nuevo estudio de Mayo Clinic descubri贸 que las personas con s铆ndrome de Tourette poseen aproximadamente la mitad de un tipo espec铆fico de c茅lula cerebral responsable de calmar los signos de movimiento hiperactivo, en comparaci贸n con las personas sin la condici贸n. Este d茅ficit puede ser una raz贸n crucial por la cual las se帽ales motoras no se controlan adecuadamente, lo que lleva a los tics involuntarios que caracterizan el trastorno.

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A new Mayo Clinic study finds that people with Tourette syndrome have about half as many of a specific type of brain cell that helps calm overactive movement signals as people without the condition. This deficit may be a key reason why their motor signals go unchecked, leading to the involuntary tics that define the disorder.

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Capitalizing on the flexibility of tiny cells inside the body鈥檚 smallest blood vessels may be a powerful spinal cord repair strategy, new research suggests.

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A team of researchers from the University of Chicago, in collaboration with researchers from the University of Pittsburgh, has identified a novel oncometabolite that accumulates in tumors and impairs immune cells' ability to fight cancer.

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An international research collaboration led by Rutgers University-New Brunswick scientists that examined microscopic blobs of protein found in human cells has discovered that some morph from an almost honey-like substance to a hard candy-like solid. These mysterious droplets, known as biomolecular condensates, solidify when they carry a high proportion of the protein alpha-synuclein, the scientists reported in Science Advances. Clumps of alpha-synuclein are commonly found in the brain cells of people with Parkinson鈥檚 disease, a neurodegenerative brain disorder.

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John N. Weinstein, M.D., Ph.D., chair of Bioinformatics and Computational Biology and professor of Systems Biology at The University of Texas MD Anderson Cancer Center, has been elected to the 2025 class of Fellows of the American Association for Cancer Research (AACR) Academy in recognition of decades of combined laboratory and computational work pioneering multi-omic molecular profiling, including the introduction of new laboratory techniques, clustered heat maps, and early innovations in artificial intelligence for cancer drug discovery.

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A team of researchers successfully created more effective immune cells that can fight cancer without damaging healthy tissue.

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Cell Therapy for Brain Tumors: Foundation Hosts Focused Ultrasound Roundtable

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Fast, cost-effective identification of safe protein insertion sites could enable advanced biosensors and multi-functional proteins

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Wistar and collaborators have discovered a type of 鈥渕olecular glue鈥� that can be used to inhibit certain pathological protein interactions.