BACKGROUNDStem cells from apical papilla (SCAPs) represent promising candidates for bone regenerative therapies due to their osteogenic potential. However, enhancing their differentiation capacity remains a critical challenge. Enhancer of z
BACKGROUNDMesenchymal stem cell (MSC)-based therapy may be a future treatment for myocardial infarction (MI). However, few studies have assessed the therapeutic efficacy of adipose tissue-derived MSCs (ADSCs) obtained from elderly patients
BACKGROUNDIn vivo degradation of bone scaffolds is significantly influenced by osteoclast (OC) activity, which is orchestrated by the interplay between receptor activator of nuclear factor-kappa B ligand (RANKL) and osteoprotegerin (OPG). T
Endometrial thickness plays an important role in successful embryo implantation and normal pregnancy achievement. However, a thin endometrial layer (鈮� 7 mm) may have a significant effect on microenvironment tolerance, which is further rel
Intervertebral disc degeneration is a leading cause of lower back pain and is characterized by pathological processes such as nucleus pulposus cell apoptosis, extracellular matrix imbalance, and annulus fibrosus rupture. These pathological
BACKGROUNDThere is currently no effective treatment for osteoarthritis (OA), which is the most common joint disorder leading to disability. Although human umbilical cord mesenchymal stem cells (hUC-MSCs) are promising OA treatments, their u
BACKGROUNDThin endometrium, leading cause of recurrent implantation failure and infertility, has been found to respond to exosomes. AIMTo investigate the efficacy of exosomes in addressing the issue of thin endometrium. METHODSRNA sequenc
In this editorial, we comment on the recent article by Xiao et al, focusing on their investigation into whether the therapeutic efficacy of serum-free human umbilical cord mesenchymal stem cells (MSCs) differs from that of serum-containing
The treatment of complex wounds presents a significant clinical challenge due to the limited availability of standardized therapeutic options. Adipose-derived stem cell exosomes (ADSC-Exos) are promising for their capabilities to enhance an
The article by Granjeiro et al provided a thorough review of the role of stem cell models in the development of advanced therapy medicinal products. It emphasized the potential of stem cell models to refine preclinical studies and align wit
BACKGROUNDMesenchymal stem cell-derived extracellular vesicles (MSC-EVs) can traverse the blood-brain barrier due to their small size. This characteristic makes them a research hotspot for the treatment of Parkinson鈥檚 disease (PD) and is
Dry eye disease (DED) is a multifactorial disorder that disturbs ocular surface equilibrium, considerably diminishing quality of life. Present therapies only offer symptomatic alleviation. Stem cell treatment, especially mesenchymal stem ce
Cedars-Sinai is a leading transplant center, with patient outcomes that consistently meet or exceed national averages. One continuing challenge, however, is the need to suppress transplant patients鈥� immune systems to prevent their bodies from rejecting the transplant.
The Cedars-Sinai Board of Governors Regenerative Medicine Institute is marking its 15th anniversary by further expanding its commitment to research, development of cell-based human models and therapies, and education with three new leadership appointments and the creation of a master鈥檚 degree program.
New research suggests that decreased activity of ELOVL2 鈥� a key enzyme in lipid metabolism 鈥� accelerates white blood cell aging and alters genes associated with the onset of blood cancers.
A Ludwig Cancer Research study has identified a novel strategy for treating acute myelogenous leukemia (AML), an aggressive blood cancer for which the median survival time following diagnosis remains just 8.5 months.
CRCHUM researchers reveal that the guinea pig pre-implantation embryo is very similar to the human embryo, spurring a better understanding of infertility and early human development.
UdeM scientists use a combination of experimental data and modelling to reveal how physical forces help plants to generate their complex 3D shapes.
UCLA researchers have identified collagen as a key factor in kidney fibrosis, revealing its potential as a biomarker to predict chronic kidney disease progression. A repurposed anti-cancer drug, Cilengitide, was found to reduce kidney scarring and slow disease progression in preclinical models, suggesting a possible precision medicine approach for high-risk patients.
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