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Ines Iba帽ez-Tallon is revealing how an understudied region of the brain plays an outsized role in opioid and nicotine dependence.

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April is designated as Alcohol Awareness Month across the nation.

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Researchers from Lawrence Livermore National Laboratory (LLNL), in collaboration with other leading institutions, have successfully used an AI-driven platform to preemptively optimize an antibody to neutralize a broad diversity of SARS-CoV-2 variants.

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Patients hospitalized with opioid use disorders who receive addiction consultation services are significantly more likely to start medication treatment and access follow-up care when compared with patients who receive standard or usual care, a study co-led by Cedars-Sinai investigators found.

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The Icahn School of Medicine at Mount Sinai has launched the AI Small Molecule Drug Discovery Center, a bold endeavor that harnesses artificial intelligence (AI) to revolutionize drug development. The new Center will integrate AI with traditional drug discovery methods to identify and design new small-molecule therapeutics with unprecedented speed and precision. Unlike conventional drug discovery, which can take years and cost billions, AI-driven approaches enable researchers to rapidly navigate a vast chemical landscape, including natural products, to pinpoint promising drug candidates. By leveraging Mount Sinai鈥檚 world-leading expertise in machine learning, chemical biology, and biomedical data science, the Center aims to bring innovative treatments to patients faster鈥攑articularly for diseases with urgent unmet needs, including cancer, metabolic disorders, and neurodegenerative diseases.

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Young adults in pain start using cannabis earlier and are more likely to mix it with alcohol, according to new research from Binghamton University, State University of New York.

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Researchers at UC San Diego have confirmed the presence of xylazine in the illicit drug supply at the U.S.-Mexico border. While xylazine remains less common in the Western U.S., border cities serve as key trafficking hubs and may have higher rates of emerging substances.

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Male and female rats with a chronic pain condition release different amounts of dopamine when given fentanyl because of sex hormones, according to a new study from WashU Medicine. The findings might help explain why men have higher rates of opioid use and overdose deaths.

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Researchers at WashU Medicine and Stanford University developed a compound that relieves pain in mice but doesn't affect the brain, thereby avoiding mind-altering side effects and abuse potential. The custom-designed molecule, derived from cannabis, may provide an alternative to opioids for treating chronic pain.

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Neuroscience grads studied how to make opioids safer

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Researchers at The University of Texas MD Anderson Cancer Center have developed a novel antibody-toxin conjugate (ATC) designed to stimulate immune-mediated eradication of tumors. According to preclinical results published today in Nature Cancer, the new approach combined the benefits of more well-known antibody-drug conjugates (ADCs) with those of immunotherapies.