麻豆传媒

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More than 100 experts in molecular simulation, coordinated by IRB Barcelona, have published an article in Nature Methods advocating for a paradigm shift in molecular dynamics data management. The article defends the implementation of the FAIR principles (Findable, Accessible, Interoperable, Reusable) to improve the reproducibility of calculations and facilitate their later use as a source of information on the flexibility of biomacromolecules. Led by Drs. Modesto Orozco and Adam Hospital, the article proposes the establishment of a shared infrastructure for storing and reusing data in the context of the AI revolution.

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鈥� A study from IRB Barcelona, funded by Fundaci贸n CRIS contra el c谩ncer demonstrates that the 鈥減revious state鈥� of blood stem cells plays a decisive role in the subtype of leukaemia that develops. 鈥� The new technique, called STRACK, allows monitoring of the evolution of each cell before and after acquiring oncogenic mutations.

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A study by IRB Barcelona unveils how the lack of a fraction of the CPEB4 protein causes a decrease in the expression of genes that are crucial for neuronal development. Published in the journal Nature, the study opens new avenues for the development of targeted treatments for autism.

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鈥� Two complementary research articles, published simultaneously in the journals Science and Cell Stem Cell by a team of scientists from the UPF and IRB Barcelona, reveal that central and peripheral circadian clocks coordinate to regulate the daily activity of skin and muscles. 鈥� The coordination between the two clocks (central and peripheral) guarantees 50% of the circadian functions of tissues, including vital processes such as the cell cycle, DNA repair, mitochondrial activity, and metabolism. 鈥� Synchronisation between the central brain clock and peripheral ones prevents premature muscle ageing and improves muscle function, suggesting new strategies to tackle age-related decline through circadian rhythm modulation.

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The protein Asc-1 serves as the gateway (either for entry or exit) for fundamental amino acids involved in cognitive processes. A new study now unveils its structure and mechanism of action.

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Researchers at IRB Barcelona report mutation rate variation across the human genome. Regions with low mutation rates correlate with hypomethylation (low methylation levels), a way cells control which genes are turned on or off.

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A team from IRB Barcelona and Sant Joan de D茅u Hospital 路 IRSJD has studied the cases of four children who have experienced two cancers during childhood and has addressed the origin of the second tumour.

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- The TRIP initiative establishes three new joint laboratories that bring together fundamental biomedical research and clinical research with the aim of accelerating the delivery of results to patients. - TRIP will focus on emerging fields such as immuno-oncology, inflammation, and cellular senescence.

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Protein degraders offer a novel approach to targeting undruggable diseases by hijacking the cell's degradation machinery.

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Researchers from IRB Barcelona describe a mechanism by which senescent cells generated by chemotherapy survive inside tumours.

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The research, which was conducted on mice, demonstrates how these tiny nanomachines are propelled by urea present in urine and precisely target the tumour, attacking it with a radioisotope carried on their surface.

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Identification of genes under recent selection provides insights into the molecular mechanisms of human-related adaptation in Candida pathogens.

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Researchers at IRB Barcelona discover unexpected patterns in mutation risks across individuals, uncovering 13 distinct genomic patterns.

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鈥� Researchers at IRB Barcelona reveal the pivotal role of iron accumulation in the development of fibrotic diseases and propose that iron detection via MRI can serve to diagnose fibrosis. 鈥� Fibrotic diseases account for 45% of all mortality in developed countries. 鈥� Published in Nature Metabolism, the study points to new therapeutic opportunities that target iron.

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Many of the most potent human oncoproteins belong to a class of proteins called transcription factors, but designing small molecule drugs that target transcription factors is a major challenge.

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A team of researchers describes in Nature Cell Biology the mechanism by which the MEC-2 protein condensates of the touch receptor neurons transition from fluid to solid-like states, switching their role in the transmission of mechanical forces. These findings pave the way for developing innovative therapies and treatments.

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Spain is the first country in the world to have this technology 鈥� Results showing the clinical utility of the test were published in Lancet Oncology and the Journal of National Cancer Institute 鈥� The test is now available to oncologists and pathologists and will benefit an estimated 24,000 patients each year in Spain

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Chromosomal instability is a phenomenon characterised by rapid changes in the number and structure of chromosomes during cell division. It is very common in solid tumours and it is linked to the aggressive spread of cancer, that is to say, metastasis.

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A collaborative study undertaken by the Navarrabiomed Biomedical Research Center (Pamplona, Navarre), the Institute of Neurosciences CSIC-UMH (Sant Joan d鈥橝lacant, Valencian Community) and IRB Barcelona (Barcelona, Catalonia) shows that the administration of ranolazine, a drug currently used to treat heart conditions, improves the efficacy of current therapies for melanoma, in mouse models of this disease.

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Researchers at IRB Barcelona identify critical spots on the genome where gene editing could cause an unwanted response, and they provide recommendations for safer approaches.