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鈥� Combining Lynparza (olaparib) and Keytruda (pembrolizumab) showed antitumor activity in multiple cancer types, particularly those with BRCA1/2 mutations 鈥� Combination demonstrated complete responses and partial responses in different cancer types, including those beyond the currently approved indications for these therapies
A new study from researchers at Moffitt Cancer Center shows that blocking a chemical process called nitrosylation could make one of the most aggressive forms of melanoma more treatable.
An international phase 3 clinical trial led by Washington University School of Medicine in St. Louis and Dana-Farber Brigham Cancer Center shows that patients with certain locally advanced head and neck cancers benefited from the addition of the immunotherapy drug pembrolizumab (brand name Keytruda) to standard-of-care therapy. Patients who received pembrolizumab saw greater tumor shrinkage prior to surgery and, on average, survived cancer-free almost two years longer than did patients who only received standard-of-care therapy.
Patients with locally advanced head and neck cancer who received the immune checkpoint inhibitor pembrolizumab before, during and after standard-of-care surgery had longer event-free survival without the cancer coming back and higher rates of substantial tumor shrinkage prior to surgery, according to the first interim analysis of a randomized, open-label phase 3 clinical trial led by investigators from Dana-Farber Brigham Cancer Center and Washington University School of Medicine in St. Louis.
New research has shown that hypertensive individuals who maintain optimal control of several key health risk factors鈥攕uch as blood pressure, cholesterol, and lifestyle behaviors鈥攃an significantly reduce their risk of dying prematurely. The study found that with each additional risk factor brought under control, the risk of death from cancer, cardiovascular disease, and other causes dropped substantially. Most importantly, those who achieved high levels of joint risk factor control had no greater risk of early death than people without hypertension. This suggests that a comprehensive, multi-pronged approach to managing hypertension could effectively eliminate the excess mortality risk associated with the condition.
A new method using glycan-coated magnetic nanoparticles (gMNPs) is poised to change the way we detect foodborne pathogens like Escherichia coli and Salmonella in complex food matrices such as melons, lettuce, and raw chicken. Unlike traditional methods that rely on expensive antibodies or lengthy enrichment processes, this innovation offers a rapid detection system that extracts and confirms pathogens through qPCR in less than four hours. The gMNPs bind efficiently to pathogens, even in the presence of natural microbiota, across a wide range of pH levels and food matrices. At just $0.50 per test and without the need for cold storage, this approach has the potential to significantly reduce the global burden of foodborne illnesses.
A groundbreaking study of Chittagong City exposes how governance gaps and infrastructure failures exacerbate urban flooding, proposing 10 key strategies combining engineering solutions with community engagement to build climate-resilient cities.
With the rapid development of the space industry, enhancing the stealth and survivability of spacecraft has become a critical challenge. Professor Qiang Li's team at Zhejiang University has developed an innovative multilayer thin-film camouflage device, enabling invisibility across H, K, MWIR, and LWIR bands while efficiently radiating heat to address thermal control issues in space. This technology achieves precise management of solar and thermal radiation, offering significant support for future space exploration.
Clear aligners have emerged as a popular alternative to traditional braces, offering aesthetic and comfort advantages. However, their unique biomechanical properties and material characteristics present distinct clinical challenges. A recent expert consensus provides comprehensive guidelines for optimizing clear aligner therapy (CAT), covering case selection, treatment principles, and clinical procedures. The study highlights the importance of tailored strategies for different tooth movements, such as molar distalization and arch expansion, and introduces a novel assessment tool to grade treatment difficulty. By addressing potential complications and emphasizing patient-specific approaches, this consensus aims to enhance treatment efficacy and broaden the adoption of clear aligners in orthodontic practice.
A recent study has revealed that KIAA1199, a secreted protein produced by bone marrow cells, plays a crucial role in regulating both fat formation and overall energy metabolism. The protein's impact extends beyond bone remodeling, influencing glucose and lipid metabolism. Mice lacking KIAA1199 showed reduced fat mass, improved insulin sensitivity, and a decreased risk of obesity-related diseases. These findings suggest that targeting KIAA1199 could lead to new therapeutic strategies for combating metabolic disorders like obesity and type 2 diabetes.
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