麻豆传媒

Chronic inflammation underlies pathologies as seemingly diverse as cancer, allergy, and a festering wound. My research focuses on discovering the dysfunctional molecular signals and circuitry causing cells to become bad actors, and why some people are more prone to these problems than others. In the lab we do this by examining signal transduction in cells differentiated from adult stem cells, particularly mast cells, macrophages, immature myeloid cells, and different populations of mesenchymal stem cells. We also use in vivo modeling to observe the consequences of targeting certain pathways in inflammatory diseases. The lab's broad areas include (1) Mast Cell Biology; (2) Inflammatory Modulation; and (3) Immune Cell Dynamics in Cancer. Our ultimate goals are to better understand the diversity of innate and adaptive immune responses, and contribute knowledge to more individually tailored approaches for treatment. Current projects include: Signaling networks (esp. TGF-β1) and differential expression of myeloid cells during inflammation and in response to immunosuppression Off-label drug uses and novel compounds, such as plant alkaloids and cannabinoids, for healthful resolution of inflammatory responses Cellular & molecular mechanisms underlying complementary and integrative health practices such as exercise. Trained immunity (a.k.a. "innate memory") of mast cells in cancer and autoimmunity Targeting mast cell specific receptors during inflammation Education Postdoctoral: Molecular Immunology, Department of Biology, Virginia Commonwealth University, Richmond, VA Ph.D.: Anatomy & Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, VA B.S.: Biology, James Madison University, Harrisonburg, VA Professional Affiliations: American Association of Immunologists Society for Leukocyte Biology American Association for Anatomy American Association for the Advancement of Science

Clayton Runfalo, MD, practices family medicine at Ochsner Health Center - Gonzales in Gonzales, Louisiana, and is the Ochsner director of community outreach and development in Ascension Parish. He is frequently interviewed on a wide range of topics, including men's health issues, rural health, vaccines, nutrition and weight loss. 
Dr. Runfalo earned a medical degree from Louisiana State University Health Sciences Center New Orleans. He completed an internship in rural family medicine with the Bogalusa Medical Center-Our Lady of the Angels Hospital in Bogalusa, Louisiana, and a residency in family medicine with Baton Rouge General Hospital. He is certified by the American Board of Family Medicine.