antisynthetase syndrome, Dermatomyositis, Inclusion Body Myositis, Myositis, necrotizing myopathy, Polymyositis
Andrew Mammen, MD, PhD works at the National Institute of Arthritis and Musculoskeletal and Skin Diseases as Muscle Disease Unit Leader in the Laboratory of Muscle Stem Cells and Gene Regulation. Prior to his appointment at NIH, he was Associate Professor of Neurology and Medicine at the Johns Hopkins University School of Medicine. He co-founded the Johns Hopkins Myositis Center in 2007, where he continues to see myositis patients as an adjunct faculty member. Dr. Mammen and his colleagues at Hopkins discovered a novel form of autoimmune myopathy associated with statin use and autoantibodies recognizing HMG-CoA reductase, the pharmacologic target of statins. In addition to clinical studies involving myositis patients, his current laboratory research interests include defining pathogenic mechanisms in the various forms of autoimmune myopathy and understanding the role of myositis autoantigens in muscle regeneration.
Dermatomyositis, Juvenile Arthritis, Lupus, Osteomyelitis, Uveitis, Vasculitis
Chief of Pediatric Rheumatology at Hospital for Special Surgery (HSS), Karen Onel, MD, cares for children and teens with arthritis and other autoimmune disorders. In particular, she diagnoses and treats: lupus, juvenile arthritis, vasculitis, uveitis (an inflammatory disorder of the eye), chronic non-infectious osteomyelitis, dermatomyositis and the periodic fever syndromes. Her goal is to work with the patient and his/her family to create a long-term care plan that will lead to improved quality of life. Dr. Onel's research focuses on gaining a greater understanding of the causes of rheumatic illnesses, as well as evaluating the safety and tolerability of new treatments. She is collaborating with other institutions to define evidence-based best treatment practices for children with JIA, SLE, and recurrent non-infectious osteomyelitis. Dr. Onel has authored numerous papers, reviews, and book chapters on pediatric rheumatology. In addition, she serves as a reviewer for several scientific journals, including Arthritis and Rheumatism, Lupus, Seminars in Arthritis and Rheumatism, and Pediatric Rheumatology. Pediatrics, Rheumatology